Българска асоциация по патология

Prognostic value of histopathological DCIS features in a large‑scale international interrater reliability study

Breast Cancer Research and Treatment Abstract Purpose For optimal management of ductal carcinoma in situ (DCIS), reproducible histopathological assessment is essential to distinguish low-risk from high-risk DCIS. Therefore, we analyzed interrater reliability of histopathological DCIS features and assessed their associations with subsequent ipsilateral invasive breast cancer (iIBC) risk. Methods Using a case-cohort design, reliability was assessed in a population-based, nationwide cohort of 2767 women with screen-detected DCIS diagnosed between 1993 and 2004, treated by breast-conserving surgery with/without radiotherapy (BCS ±…

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Was the COVID-19 Test Meant to Detect a Virus?

The Corona Simulation Machine: Why the Inventor of The “Corona Test” Would Have Warned Us Not To Use It To Detect A Virus “Scientists are doing an awful lot of damage to the world in the name of helping it. I don’t mind attacking my own fraternity because I am ashamed of it.” –Kary Mullis, Inventor of Polymerase Chain Reaction What do we mean when we say somebody has ‘tested positive’ for the Corona Virus? The answer would astound you.…

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A Matter of Life or Death

In memory of Professor Juan Rosai Juan Rosai, M.D. (August 1940 – July 2020)  Despite all the advances in molecular pathology and other disciplines, the diagnosis of solid tumours today is still based in the overwhelming majority of the cases on what we see under the microscope. Juan Rosai was born in Italy as World War II began and emigrated with his family to Argentina at the age of eight.  He fulfilled his immigrant parents’ ‘dream’ by becoming a doctor. …

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