The pro-apoptotic role of autophagy in breast cancer

Background: Autophagy is a catabolic process that has a vital role in cancer progression and treatment. Current chemotherapeutic agents, which target autophagy, result in growth inhibition in many cancer types. In this study, we examined the role of autophagy in breast cancer (BCa) patients as well as BCa cell lines. Methods: Tissue microarray was used to detect the expression of an autophagy marker, LC3B in BCa patients (normal/ hyperplasia ¼ 8; grade-I ¼ 15, grade-II ¼ 84, and grade-III ¼…

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