A summary Received: 22 January 2016 / Revised: 8 February 2016 / Accepted: 9 February 2016 / Published online: 9 May 2016 © Springer-Verlag Berlin Heidelberg 2016
CASE N°50 from https://icytology.wordpress.com
From Pathology – Research and Practice 212 (2016) 583–597 pp.
Its predictive and prognostic value in HER2-positive breast cancer treated with trastuzumab-based neoadjuvant chemotherapy
Head and Neck Pathol (2016) 10:75–84 DOI 10.1007/s12105-016-0695-8
Background: Autophagy is a catabolic process that has a vital role in cancer progression and treatment. Current chemotherapeutic agents, which target autophagy, result in growth inhibition in many cancer types. In this study, we examined the role of autophagy in breast cancer (BCa) patients as well as BCa cell lines. Methods: Tissue microarray was used to detect the expression of an autophagy marker, LC3B in BCa patients (normal/ hyperplasia ¼ 8; grade-I ¼ 15, grade-II ¼ 84, and grade-III ¼…